B cell targeted therapies in autoimmune disease
نویسندگان
چکیده
منابع مشابه
B cell targeted therapies
Although the precise pathogenesis of rheumatoid arthritis (RA) remains unclear, many cell populations, including monocytes, macrophages, endothelial cells, fibroblasts and B cells, participate in the inflammatory process. Ongoing research continues to evaluate the critical roles played by B cells in sustaining the chronic inflammatory process of RA. These findings have contributed to the develo...
متن کاملProspects for B-cell-targeted therapy in autoimmune disease.
Reasons for targeting B cells in autoimmune disease date back to the discovery of autoantibodies over 50 yr ago [1]. The idea became of practical interest when anti-B cell monoclonal antibodies were developed in the early 1990s [2, 3]. Fortuitously, at about the same time it became clear that B cells are not simply the subordinate foot soldiers of an immune response but may be as important as T...
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B-lymphocytes are programmed for the production of immunoglobulin (Ig) after antigen presentation, in the context of T-lymphocyte control within lymphoid organs. During this differentiation/activation process, B-lymphocytes exhibit different restricted or common surface markers, activation of cellular pathways that regulate cell cycle, metabolism, proteasome activity, and protein synthesis. All...
متن کاملParadox of B cell-targeted therapies.
The use of antibodies against the human B cell surface protein CD20 represents the most advanced therapeutic approach among the B cell-depleting armamentarium for the treatment of autoimmune disorders. However, recent evidence indicates that B cells can also be essential for suppressing unwanted autoaggressive T cell responses, and therefore, a more careful evaluation of which types of autoimmu...
متن کاملB-cell–targeted therapies in relapsing forms of MS
In recent years, there has been a significant increase in the therapeutic options available for the management of relapsing forms of MS. Therapies primarily targeting B cells, including therapeutic anti-CD20 monoclonal antibodies, have been evaluated in phase I, phase II, and phase III clinical trials. Results of these trials have shown their efficacy and relatively tolerable adverse effect pro...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2019
ISSN: 0952-7915
DOI: 10.1016/j.coi.2019.09.004